Radiosynthesis of the Tumor Hypoxia Marker [(18)F]TFMISO via O-[(18)F]Trifluoroethylation Reveals a Striking Difference Between Trifluoroethyl Tosylate and Iodide in Regiochemical Reactivity Toward Oxygen Nucleophiles

The MRI hypoxia marker trifluoro-misonidazole (TFMISO) [1-(2-nitro-1H-imidazol-1-yl)-3-(2,2,2-trifluoroethoxy)propan-2-ol] was successfully labeled with (18)F to expand its role into a bimodal PET/MRI probe. (18)F-Labeling was achieved via a 3-step procedure in which 2,2,2-[(18)F]trifluoroethyl p-to...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Suehiro, Makiko, Yang, Guangbin, Torchon, Geralda, Ackerstaff, Ellen, Humm, John, Koutcher, Jason, Ouerfelli, Ouathek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072420/
https://ncbi.nlm.nih.gov/pubmed/21398131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.026
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