Alpha radioimmunotherapy using (225)Ac-proteus-DOTA for solid tumors - safety at curative doses

This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using (225)Ac and its theranostic pair, (111)In. We call our novel tumor-targeting DOTA-hapten PRIT system “proteus-DOTA” or “Pr.” Herein we report the first results of radiochemistry development, radiopharmacology, and...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Cheal, Sarah M., McDevitt, Michael R., Santich, Brian H., Patel, Mitesh, Yang, Guangbin, Fung, Edward K., Veach, Darren R., Bell, Meghan, Ahad, Afruja, Vargas, Daniela Burnes, Punzalan, Blesida, Pillarsetty, Naga Vara Kishore, Xu, Hong, Guo, Hong-fen, Monette, Sébastien, Michel, Adam O., Piersigilli, Alessandra, Scheinberg, David A., Ouerfelli, Ouathek, Cheung, Nai-Kong V., Larson, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546012/
https://ncbi.nlm.nih.gov/pubmed/33052220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48810
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