Alpha radioimmunotherapy using (225)Ac-proteus-DOTA for solid tumors - safety at curative doses

This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using (225)Ac and its theranostic pair, (111)In. We call our novel tumor-targeting DOTA-hapten PRIT system “proteus-DOTA” or “Pr.” Herein we report the first results of radiochemistry development, radiopharmacology, and...

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書誌詳細
出版年:Theranostics
主要な著者: Cheal, Sarah M., McDevitt, Michael R., Santich, Brian H., Patel, Mitesh, Yang, Guangbin, Fung, Edward K., Veach, Darren R., Bell, Meghan, Ahad, Afruja, Vargas, Daniela Burnes, Punzalan, Blesida, Pillarsetty, Naga Vara Kishore, Xu, Hong, Guo, Hong-fen, Monette, Sébastien, Michel, Adam O., Piersigilli, Alessandra, Scheinberg, David A., Ouerfelli, Ouathek, Cheung, Nai-Kong V., Larson, Steven M.
フォーマット: Artigo
言語:Inglês
出版事項: Ivyspring International Publisher 2020
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546012/
https://ncbi.nlm.nih.gov/pubmed/33052220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48810
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