Alpha radioimmunotherapy using (225)Ac-proteus-DOTA for solid tumors - safety at curative doses

This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using (225)Ac and its theranostic pair, (111)In. We call our novel tumor-targeting DOTA-hapten PRIT system “proteus-DOTA” or “Pr.” Herein we report the first results of radiochemistry development, radiopharmacology, and...

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Veröffentlicht in:Theranostics
Hauptverfasser: Cheal, Sarah M., McDevitt, Michael R., Santich, Brian H., Patel, Mitesh, Yang, Guangbin, Fung, Edward K., Veach, Darren R., Bell, Meghan, Ahad, Afruja, Vargas, Daniela Burnes, Punzalan, Blesida, Pillarsetty, Naga Vara Kishore, Xu, Hong, Guo, Hong-fen, Monette, Sébastien, Michel, Adam O., Piersigilli, Alessandra, Scheinberg, David A., Ouerfelli, Ouathek, Cheung, Nai-Kong V., Larson, Steven M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546012/
https://ncbi.nlm.nih.gov/pubmed/33052220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48810
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