Alpha radioimmunotherapy using (225)Ac-proteus-DOTA for solid tumors - safety at curative doses

This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using (225)Ac and its theranostic pair, (111)In. We call our novel tumor-targeting DOTA-hapten PRIT system “proteus-DOTA” or “Pr.” Herein we report the first results of radiochemistry development, radiopharmacology, and...

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Publicat a:Theranostics
Autors principals: Cheal, Sarah M., McDevitt, Michael R., Santich, Brian H., Patel, Mitesh, Yang, Guangbin, Fung, Edward K., Veach, Darren R., Bell, Meghan, Ahad, Afruja, Vargas, Daniela Burnes, Punzalan, Blesida, Pillarsetty, Naga Vara Kishore, Xu, Hong, Guo, Hong-fen, Monette, Sébastien, Michel, Adam O., Piersigilli, Alessandra, Scheinberg, David A., Ouerfelli, Ouathek, Cheung, Nai-Kong V., Larson, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546012/
https://ncbi.nlm.nih.gov/pubmed/33052220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48810
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