Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases

Extracellular diphosphate and triphosphate nucleotides are released from activated or injured cells to trigger vascular and immune P(2) purinergic receptors, provoking inflammation and vascular thrombosis. These metabokines are scavenged by ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Zhong, Elizabeth H., Ledderose, Carola, De Andrade Mello, Paola, Enjyoji, Keiichi, Lunderberg, Justin Mark, Junger, Wolfgang, Robson, Simon C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846972/
https://ncbi.nlm.nih.gov/pubmed/33052071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00430.2020
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