Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases

Extracellular diphosphate and triphosphate nucleotides are released from activated or injured cells to trigger vascular and immune P(2) purinergic receptors, provoking inflammation and vascular thrombosis. These metabokines are scavenged by ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Cell Physiol
Hoofdauteurs: Zhong, Elizabeth H., Ledderose, Carola, De Andrade Mello, Paola, Enjyoji, Keiichi, Lunderberg, Justin Mark, Junger, Wolfgang, Robson, Simon C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846972/
https://ncbi.nlm.nih.gov/pubmed/33052071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00430.2020
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