Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases

Extracellular diphosphate and triphosphate nucleotides are released from activated or injured cells to trigger vascular and immune P(2) purinergic receptors, provoking inflammation and vascular thrombosis. These metabokines are scavenged by ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Cell Physiol
Asıl Yazarlar: Zhong, Elizabeth H., Ledderose, Carola, De Andrade Mello, Paola, Enjyoji, Keiichi, Lunderberg, Justin Mark, Junger, Wolfgang, Robson, Simon C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846972/
https://ncbi.nlm.nih.gov/pubmed/33052071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00430.2020
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