Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis

Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A(2A)R) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphos...

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Detalles Bibliográficos
Publicado en:Am J Pathol
Autores principales: Fernández, Patricia, Perez-Aso, Miguel, Smith, Gideon, Wilder, Tuere, Trzaska, Sean, Chiriboga, Luis, Franks, Andrew, Robson, Simon C., Cronstein, Bruce N., Chan, Edwin S.L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2013
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362691/
https://ncbi.nlm.nih.gov/pubmed/24266925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.024
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