Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis

Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A(2A)R) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphos...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Fernández, Patricia, Perez-Aso, Miguel, Smith, Gideon, Wilder, Tuere, Trzaska, Sean, Chiriboga, Luis, Franks, Andrew, Robson, Simon C., Cronstein, Bruce N., Chan, Edwin S.L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362691/
https://ncbi.nlm.nih.gov/pubmed/24266925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.024
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