Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis

Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A(2A)R) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphos...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Fernández, Patricia, Perez-Aso, Miguel, Smith, Gideon, Wilder, Tuere, Trzaska, Sean, Chiriboga, Luis, Franks, Andrew, Robson, Simon C., Cronstein, Bruce N., Chan, Edwin S.L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362691/
https://ncbi.nlm.nih.gov/pubmed/24266925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.024
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