Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases

Extracellular diphosphate and triphosphate nucleotides are released from activated or injured cells to trigger vascular and immune P(2) purinergic receptors, provoking inflammation and vascular thrombosis. These metabokines are scavenged by ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Cell Physiol
Päätekijät: Zhong, Elizabeth H., Ledderose, Carola, De Andrade Mello, Paola, Enjyoji, Keiichi, Lunderberg, Justin Mark, Junger, Wolfgang, Robson, Simon C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846972/
https://ncbi.nlm.nih.gov/pubmed/33052071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00430.2020
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