Inhibition of neutrophils by hypertonic saline involves pannexin-1, CD39, CD73, and other ectonucleotidases

Hypertonic saline (HS) resuscitation has been studied as a possible strategy to reduce PMN activation and tissue damage in trauma patients. HS blocks PMNs by ATP release and stimulation of A2a adenosine receptors. Here we studied the underlying mechanisms in search of possible reasons for the incons...

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Bibliografiska uppgifter
I publikationen:Shock
Huvudupphovsmän: Chen, Yu, Bao, Yi, Zhang, Jingping, Woehrle, Tobias, Sumi, Yuka, Ledderose, Stephan, Li, Xiaoou, Ledderose, Carola, Junger, Wolfgang G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537693/
https://ncbi.nlm.nih.gov/pubmed/26009814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000402
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