Inhibition of neutrophils by hypertonic saline involves pannexin-1, CD39, CD73, and other ectonucleotidases

Hypertonic saline (HS) resuscitation has been studied as a possible strategy to reduce PMN activation and tissue damage in trauma patients. HS blocks PMNs by ATP release and stimulation of A2a adenosine receptors. Here we studied the underlying mechanisms in search of possible reasons for the incons...

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Pubblicato in:Shock
Autori principali: Chen, Yu, Bao, Yi, Zhang, Jingping, Woehrle, Tobias, Sumi, Yuka, Ledderose, Stephan, Li, Xiaoou, Ledderose, Carola, Junger, Wolfgang G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537693/
https://ncbi.nlm.nih.gov/pubmed/26009814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000402
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