The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centrosome clustering is therefore considered a promising...

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Pubblicato in:Nat Commun
Autori principali: Fan, Guangjian, Sun, Lianhui, Meng, Ling, Hu, Chen, Wang, Xing, Shi, Zhan, Hu, Congli, Han, Yang, Yang, Qingqing, Cao, Liu, Zhang, Xiaohong, Zhang, Yan, Song, Xianmin, Xia, Shujie, He, Baokun, Zhang, Shengping, Wang, Chuangui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782532/
https://ncbi.nlm.nih.gov/pubmed/33397932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20208-x
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