The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centrosome clustering is therefore considered a promising...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Fan, Guangjian, Sun, Lianhui, Meng, Ling, Hu, Chen, Wang, Xing, Shi, Zhan, Hu, Congli, Han, Yang, Yang, Qingqing, Cao, Liu, Zhang, Xiaohong, Zhang, Yan, Song, Xianmin, Xia, Shujie, He, Baokun, Zhang, Shengping, Wang, Chuangui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782532/
https://ncbi.nlm.nih.gov/pubmed/33397932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20208-x
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