The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centrosome clustering is therefore considered a promising...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Fan, Guangjian, Sun, Lianhui, Meng, Ling, Hu, Chen, Wang, Xing, Shi, Zhan, Hu, Congli, Han, Yang, Yang, Qingqing, Cao, Liu, Zhang, Xiaohong, Zhang, Yan, Song, Xianmin, Xia, Shujie, He, Baokun, Zhang, Shengping, Wang, Chuangui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782532/
https://ncbi.nlm.nih.gov/pubmed/33397932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20208-x
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky