Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression and malignancy. This is mediated through activation of transcription factors like hypoxia-inducible factor 1 (HIF-1) and c-Myc, yet the impact of hypoxia on negative regulato...

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Udgivet i:PLoS Biol
Main Authors: Shi, Yi, Liu, Ze, Zhang, Qian, Vallee, Ingrid, Mo, Zhongying, Kishi, Shuji, Yang, Xiang-Lei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755189/
https://ncbi.nlm.nih.gov/pubmed/33351793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000991
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