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Designing seryl-tRNA synthetase for improved serylation of selenocysteine tRNAs
Selenocysteine (Sec) lacks a cognate aminoacyl-tRNA synthetase. Instead, seryl-tRNA synthetase (SerRS) produces Ser-tRNA(Sec), which is subsequently converted by selenocysteine synthase to Sec-tRNA(Sec). Escherichia coli SerRS serylates tRNA(Sec) poorly; this may hinder efficient production of desig...
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| Published in: | FEBS Lett |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6263840/ https://ncbi.nlm.nih.gov/pubmed/30317559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13271 |
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