Loss of KLF14 triggers centrosome amplification and tumorigenesis

Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional...

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Udgivet i:Nat Commun
Main Authors: Fan, Guangjian, Sun, Lianhui, Shan, Peipei, Zhang, Xianying, Huan, Jinliang, Zhang, Xiaohong, Li, Dali, Wang, Tingting, Wei, Tingting, Gu, Xiaoyang, Yao, Liangfang, Xuan, Yang, Hou, Zhaoyuan, Cui, Yongping, Cao, Liu, Li, Xiaotao, Zhang, Shengping, Wang, Chuangui
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600754/
https://ncbi.nlm.nih.gov/pubmed/26439168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9450
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