Chronic centrosome amplification without tumorigenesis

Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle assembly and chromosome segregation. Recognizing that centrosome amplification is a common feature of aneuploid cancer cells, we tested whether supernumerary centrosomes are sufficient to drive tumor development....

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Vitre, Benjamin, Holland, Andrew J., Kulukian, Anita, Shoshani, Ofer, Hirai, Maretoshi, Wang, Yin, Maldonado, Marcus, Cho, Thomas, Boubaker, Jihane, Swing, Deborah A., Tessarollo, Lino, Evans, Sylvia M., Fuchs, Elaine, Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655534/
https://ncbi.nlm.nih.gov/pubmed/26578792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519388112
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