The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centrosome clustering is therefore considered a promising...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fan, Guangjian, Sun, Lianhui, Meng, Ling, Hu, Chen, Wang, Xing, Shi, Zhan, Hu, Congli, Han, Yang, Yang, Qingqing, Cao, Liu, Zhang, Xiaohong, Zhang, Yan, Song, Xianmin, Xia, Shujie, He, Baokun, Zhang, Shengping, Wang, Chuangui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782532/
https://ncbi.nlm.nih.gov/pubmed/33397932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20208-x
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