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Phosphorylation of Cyclin D1 Regulated by ATM or ATR Controls Cell Cycle Progression
Cyclin D1 is required at high levels for passage through G(1) phase but must be reduced to low levels during S phase to avoid the inhibition of DNA synthesis. This suppression requires the phosphorylation of Thr286, which is induced directly by DNA synthesis. Because the checkpoint kinase ATR is act...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519724/ https://ncbi.nlm.nih.gov/pubmed/18606783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02047-07 |
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