Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations

Chromosomal translocations are hallmarks of various types of cancers and leukemias. However, the molecular mechanisms of chromosome translocations remain largely unknown. The ataxia-telangiectasia mutated (ATM) protein, a DNA damage signaling regulator, facilitates DNA repair to prevent chromosome a...

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Bibliographic Details
Published in:eLife
Main Authors: Sun, Jiying, Shi, Lin, Kinomura, Aiko, Fukuto, Atsuhiko, Horikoshi, Yasunori, Oma, Yukako, Harata, Masahiko, Ikura, Masae, Ikura, Tsuyoshi, Kanaar, Roland, Tashiro, Satoshi
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953535/
https://ncbi.nlm.nih.gov/pubmed/29759113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32222
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