CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression

In budding yeast, the essential functions of Hsp70 chaperones Ssa1–4 are regulated through expression level, isoform specificity, and cochaperone activity. Suggesting a novel regulatory paradigm, we find that phosphorylation of Ssa1 T36 within a cyclin-dependent kinase (CDK) consensus site conserved...

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Detalhes bibliográficos
Main Authors: Truman, Andrew W., Kristjansdottir, Kolbrun, Wolfgeher, Donald, Hasin, Naushaba, Polier, Sigrun, Zhang, Hong, Perrett, Sarah, Prodromou, Chrisostomos, Jones, Gary W., Kron, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778871/
https://ncbi.nlm.nih.gov/pubmed/23217712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.051
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