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TRF2-independent chromosome end protection during pluripotency
Mammalian telomeres protect chromosome ends from aberrant DNA repair(1). TRF2, a component of the telomere-specific Shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within a lariat t-loop structure(2,3). Deleting Trf2 in somatic cel...
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| Gepubliceerd in: | Nature |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614352/ https://ncbi.nlm.nih.gov/pubmed/33239783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2960-y |
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