TRF2-independent chromosome end protection during pluripotency

Mammalian telomeres protect chromosome ends from aberrant DNA repair(1). TRF2, a component of the telomere-specific Shelterin protein complex, facilitates end protection through sequestration of the terminal telomere repeat sequence within a lariat t-loop structure(2,3). Deleting Trf2 in somatic cel...

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Udgivet i:Nature
Main Authors: Ruis, Phil, Van Ly, David, Borel, Valerie, Kafer, Georgia R., McCarthy, Afshan, Howell, Steven, Blassberg, Robert, Snijders, Ambrosius P., Briscoe, James, Niakan, Kathy K., Marzec, Paulina, Cesare, Anthony J., Boulton, Simon J.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614352/
https://ncbi.nlm.nih.gov/pubmed/33239783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2960-y
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