TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluripotency genes, thereby exerting vast epi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Marión, Rosa María, Montero, Juan J, López de Silanes, Isabel, Graña-Castro, Osvaldo, Martínez, Paula, Schoeftner, Stefan, Palacios-Fábrega, José Alejandro, Blasco, Maria A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701927/
https://ncbi.nlm.nih.gov/pubmed/31426913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44656
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