Community guidelines for GPCR ligand bias: IUPHAR review 32

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requires that we now characterize physiological signal...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2022
Matèries:
Invited Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612872/
https://ncbi.nlm.nih.gov/pubmed/35106752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15811
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