Community guidelines for GPCR ligand bias: IUPHAR review 32

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requires that we now characterize physiological signal...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2022
Assuntos:
Invited Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612872/
https://ncbi.nlm.nih.gov/pubmed/35106752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15811
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