Community guidelines for GPCR ligand bias: IUPHAR review 32

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage different intracellular transducers. This ‘biased signalling’ paradigm requires that we now characterize physiological signal...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2022
Fag:
Invited Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612872/
https://ncbi.nlm.nih.gov/pubmed/35106752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15811
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