Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer

PURPOSE: Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin in terms of histopathology, genomic landscape, and therapeutic response, but some limitations due to costs associated with their maintenance and restricted amenability for large-scale screenings still exist....

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Lazzari, Luca, Corti, Giorgio, Picco, Gabriele, Isella, Claudio, Montone, Monica, Arcella, Pamela, Durinikova, Erika, Zanella, Eugenia R., Novara, Luca, Barbosa, Fabiane, Cassingena, Andrea, Cancelliere, Carlotta, Medico, Enzo, Sartore-Bianchi, Andrea, Siena, Salvatore, Garnett, Mathew J., Bertotti, Andrea, Trusolino, Livio, Di Nicolantonio, Federica, Linnebacher, Michael, Bardelli, Alberto, Arena, Sabrina
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611232/
https://ncbi.nlm.nih.gov/pubmed/31375513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3440
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