Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer

PURPOSE: Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin in terms of histopathology, genomic landscape, and therapeutic response, but some limitations due to costs associated with their maintenance and restricted amenability for large-scale screenings still exist....

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Udgivet i:Clin Cancer Res
Main Authors: Lazzari, Luca, Corti, Giorgio, Picco, Gabriele, Isella, Claudio, Montone, Monica, Arcella, Pamela, Durinikova, Erika, Zanella, Eugenia R., Novara, Luca, Barbosa, Fabiane, Cassingena, Andrea, Cancelliere, Carlotta, Medico, Enzo, Sartore-Bianchi, Andrea, Siena, Salvatore, Garnett, Mathew J., Bertotti, Andrea, Trusolino, Livio, Di Nicolantonio, Federica, Linnebacher, Michael, Bardelli, Alberto, Arena, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611232/
https://ncbi.nlm.nih.gov/pubmed/31375513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3440
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