Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer

PURPOSE: Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin in terms of histopathology, genomic landscape, and therapeutic response, but some limitations due to costs associated with their maintenance and restricted amenability for large-scale screenings still exist....

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Lazzari, Luca, Corti, Giorgio, Picco, Gabriele, Isella, Claudio, Montone, Monica, Arcella, Pamela, Durinikova, Erika, Zanella, Eugenia R., Novara, Luca, Barbosa, Fabiane, Cassingena, Andrea, Cancelliere, Carlotta, Medico, Enzo, Sartore-Bianchi, Andrea, Siena, Salvatore, Garnett, Mathew J., Bertotti, Andrea, Trusolino, Livio, Di Nicolantonio, Federica, Linnebacher, Michael, Bardelli, Alberto, Arena, Sabrina
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611232/
https://ncbi.nlm.nih.gov/pubmed/31375513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3440
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