Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer

PURPOSE: Patient-derived xenograft (PDX) models accurately recapitulate the tumor of origin in terms of histopathology, genomic landscape, and therapeutic response, but some limitations due to costs associated with their maintenance and restricted amenability for large-scale screenings still exist....

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lazzari, Luca, Corti, Giorgio, Picco, Gabriele, Isella, Claudio, Montone, Monica, Arcella, Pamela, Durinikova, Erika, Zanella, Eugenia R., Novara, Luca, Barbosa, Fabiane, Cassingena, Andrea, Cancelliere, Carlotta, Medico, Enzo, Sartore-Bianchi, Andrea, Siena, Salvatore, Garnett, Mathew J., Bertotti, Andrea, Trusolino, Livio, Di Nicolantonio, Federica, Linnebacher, Michael, Bardelli, Alberto, Arena, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611232/
https://ncbi.nlm.nih.gov/pubmed/31375513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3440
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