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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
CCCTC-binding factor (CTCF)-mediated stable topologically associating domains (TADs) play a critical role in constraining interactions of DNA elements that are located in neighboring TADs. CTCF plays an important role in regulating the spatial and temporal expression of HOX genes that control embryo...
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| Publicat a: | J Vis Exp |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7607627/ https://ncbi.nlm.nih.gov/pubmed/30985763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59382 |
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