CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia

HOX gene dysregulation is a common feature of acute myeloid leukemia (AML). The molecular mechanisms underlying aberrant HOX gene expression and associated AML pathogenesis remain unclear. The nuclear protein CCCTC-binding factor (CTCF), when bound to insulator sequences, constrains temporal HOX gen...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Luo, Huacheng, Wang, Fei, Zha, Jie, Li, Haoli, Yan, Bowen, Du, Qinghua, Yang, Fengchun, Sobh, Amin, Vulpe, Christopher, Drusbosky, Leylah, Cogle, Christopher, Chepelev, Iouri, Xu, Bing, Nimer, Stephen D., Licht, Jonathan, Qiu, Yi, Chen, Baoan, Xu, Mingjiang, Huang, Suming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107877/
https://ncbi.nlm.nih.gov/pubmed/29760161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-11-814319
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