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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
CCCTC-binding factor (CTCF)-mediated stable topologically associating domains (TADs) play a critical role in constraining interactions of DNA elements that are located in neighboring TADs. CTCF plays an important role in regulating the spatial and temporal expression of HOX genes that control embryo...
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| Publicado no: | J Vis Exp |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7607627/ https://ncbi.nlm.nih.gov/pubmed/30985763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59382 |
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