Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1

Dichloroacetate (DCA) is an investigational drug that is used in the treatment of various congenital and acquired disorders of energy metabolism. Although DCA is generally well tolerated, some patients experience peripheral neuropathy, a side effect more common in adults than children. Repetitive DC...

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Udgivet i:Drug Metab Dispos
Main Authors: Squirewell, Edwin J., Mareus, Ricky, Horne, Lloyd P., Stacpoole, Peter W., James, Margaret O.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589945/
https://ncbi.nlm.nih.gov/pubmed/32873592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000143
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