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Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1

Dichloroacetate (DCA) is an investigational drug that is used in the treatment of various congenital and acquired disorders of energy metabolism. Although DCA is generally well tolerated, some patients experience peripheral neuropathy, a side effect more common in adults than children. Repetitive DC...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Squirewell, Edwin J., Mareus, Ricky, Horne, Lloyd P., Stacpoole, Peter W., James, Margaret O.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589945/
https://ncbi.nlm.nih.gov/pubmed/32873592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000143
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