Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase ζ1

Dichloroacetate (DCA) is a potential environmental hazard and an investigational drug. Repeated doses of DCA result in reduced drug clearance, probably through inhibition of glutathione transferase ζ1 (GSTZ1), a cytosolic enzyme that converts DCA to glyoxylate. DCA is known to be taken up by mitocho...

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Main Authors: Li, Wenjun, James, Margaret O., McKenzie, Sarah C., Calcutt, Nigel A., Liu, Chen, Stacpoole, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Metabolism, Transport, and Pharmacogenomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014303/
https://ncbi.nlm.nih.gov/pubmed/20884751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.173195
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