Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate

Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1) maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway. The authors postu...

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Autori principali: Shroads, Albert L., Langaee, Taimour, Coats, Bonnie S., Kurtz, Tracie L., Bullock, John R., Weithorn, David, Gong, Yan, Wagner, David A., Ostrov, David A., Johnson, Julie A., Stacpoole, Peter W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786668/
https://ncbi.nlm.nih.gov/pubmed/21642471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270011405664
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