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Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited mitochondrial disorders that result in lactic acidosis, as well as pulmonary hypertension and several different solid tum...
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| Publicado no: | Pharmacol Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5274567/ https://ncbi.nlm.nih.gov/pubmed/27771434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2016.10.018 |
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