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Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1
Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited mitochondrial disorders that result in lactic acidosis, as well as pulmonary hypertension and several different solid tum...
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| Udgivet i: | Pharmacol Ther |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5274567/ https://ncbi.nlm.nih.gov/pubmed/27771434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2016.10.018 |
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