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Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1

Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited mitochondrial disorders that result in lactic acidosis, as well as pulmonary hypertension and several different solid tum...

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Bibliographic Details
Published in:Pharmacol Ther
Main Authors: James, Margaret O., Jahn, Stephan C., Zhong, Guo, Smeltz, Marci G., Hu, Zhiwei, Stacpoole, Peter W.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5274567/
https://ncbi.nlm.nih.gov/pubmed/27771434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2016.10.018
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