Regulation of Dichloroacetate Biotransformation in Rat Liver and Extrahepatic Tissues by GSTZ1 Expression and Chloride Concentration

Biotransformation of dichloroacetate (DCA) to glyoxylate by hepatic glutathione transferase zeta 1 (GSTZ1) is considered the principal determinant of the rate of plasma clearance of the drug. However, several other organismal and subcellular factors are also known to influence DCA metabolism. We uti...

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Pubblicato in:Biochem Pharmacol
Autori principali: Jahn, Stephan C., Smeltz, Marci G., Hu, Zhiwei, Rowland-Faux, Laura, Zhong, Guo, Lorenzo, Ryan J., Cisneros, Katherine V., Stacpoole, Peter W., James, Margaret O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960630/
https://ncbi.nlm.nih.gov/pubmed/29626439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.04.001
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