Regulation of Dichloroacetate Biotransformation in Rat Liver and Extrahepatic Tissues by GSTZ1 Expression and Chloride Concentration

Biotransformation of dichloroacetate (DCA) to glyoxylate by hepatic glutathione transferase zeta 1 (GSTZ1) is considered the principal determinant of the rate of plasma clearance of the drug. However, several other organismal and subcellular factors are also known to influence DCA metabolism. We uti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Jahn, Stephan C., Smeltz, Marci G., Hu, Zhiwei, Rowland-Faux, Laura, Zhong, Guo, Lorenzo, Ryan J., Cisneros, Katherine V., Stacpoole, Peter W., James, Margaret O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960630/
https://ncbi.nlm.nih.gov/pubmed/29626439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.04.001
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge