Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner

The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase ζ1 (GSTZ1). DCA is a mechanism-based inactivator of GSTZ1, thus elimination of DCA is slowed with repeated dosing. We...

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Bibliographic Details
Main Authors: Zhong, Guo, Li, Wenjun, Gu, Yuan, Langaee, Taimour, Stacpoole, Peter W., James, Margaret O.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019600/
https://ncbi.nlm.nih.gov/pubmed/24632415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.02.015
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