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The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression
BACKGROUND/OBJECTIVES: The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of...
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| Publicado no: | Pharmacogenet Genomics |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382440/ https://ncbi.nlm.nih.gov/pubmed/25738370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000129 |
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