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The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression
BACKGROUND/OBJECTIVES: The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of...
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| 出版年: | Pharmacogenet Genomics |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382440/ https://ncbi.nlm.nih.gov/pubmed/25738370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000129 |
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