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The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression

BACKGROUND/OBJECTIVES: The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of...

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書誌詳細
出版年:Pharmacogenet Genomics
主要な著者: Langaee, Taimour, Zhong, Guo, Li, Wenjun, Hamadeh, Issam, Solayman, Mohamed Hassan M., McDonough, Caitrin W., Stacpoole, Peter W., James, Margaret O.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382440/
https://ncbi.nlm.nih.gov/pubmed/25738370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000129
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