Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes

Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age 7. However, the mechan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Metab Dispos
Prif Awduron: Jahn, Stephan C., Gay, Lauren A., Weaver, Claire J., Renne, Rolf, Langaee, Taimour Y., Stacpoole, Peter W., James, Margaret O.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2020
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289049/
https://ncbi.nlm.nih.gov/pubmed/32357971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.090639
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