Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate

Glutathione transferase ζ 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several α-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors. Ag...

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Bibliografiske detaljer
Main Authors: Li, Wenjun, Gu, Yuan, James, Margaret O., Hines, Ronald N., Simpson, Pippa, Langaee, Taimour, Stacpoole, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2012
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263939/
https://ncbi.nlm.nih.gov/pubmed/22028318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041533
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