Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1

Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer. GSTZ1 is expressed in both hepatic cytosol and mitochondria. Here, we examined the ontogeny and c...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Zhong, Guo, James, Margaret O., Smeltz, Marci G., Jahn, Stephan C., Langaee, Taimour, Simpson, Pippa, Stacpoole, Peter W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2018
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6038028/
https://ncbi.nlm.nih.gov/pubmed/29853471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.081810
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