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The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression
BACKGROUND/OBJECTIVES: The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of...
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| Publicado en: | Pharmacogenet Genomics |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382440/ https://ncbi.nlm.nih.gov/pubmed/25738370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000129 |
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