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Role of Dichloroacetate in the Treatment of Genetic Mitochondrial Diseases
Dichloroacetate (DCA) is an investigational drug for the treatment of genetic mitochondrial diseases. Its primary site of action is the pyruvate dehydrogenase (PDH) complex, which it stimulates by altering its phosphorylation state and stability. DCA is metabolized by and inhibits the bifunctional z...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746325/ https://ncbi.nlm.nih.gov/pubmed/18647626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2008.02.014 |
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