Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase ζ1

Dichloroacetate (DCA) is a potential environmental hazard and an investigational drug. Repeated doses of DCA result in reduced drug clearance, probably through inhibition of glutathione transferase ζ1 (GSTZ1), a cytosolic enzyme that converts DCA to glyoxylate. DCA is known to be taken up by mitocho...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Li, Wenjun, James, Margaret O., McKenzie, Sarah C., Calcutt, Nigel A., Liu, Chen, Stacpoole, Peter W.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2011
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014303/
https://ncbi.nlm.nih.gov/pubmed/20884751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.173195
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars