Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1

Dichloroacetate (DCA) is an investigational drug that is used in the treatment of various congenital and acquired disorders of energy metabolism. Although DCA is generally well tolerated, some patients experience peripheral neuropathy, a side effect more common in adults than children. Repetitive DC...

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Publicat a:Drug Metab Dispos
Autors principals: Squirewell, Edwin J., Mareus, Ricky, Horne, Lloyd P., Stacpoole, Peter W., James, Margaret O.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589945/
https://ncbi.nlm.nih.gov/pubmed/32873592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000143
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