PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less is known about PD-1 function in regulatory T (T reg) cells. To study the role of PD-1 in T reg cells, we gene...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Tan, Catherine L., Kuchroo, Juhi R., Sage, Peter T., Liang, Dan, Francisco, Loise M., Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L., Juneja, Vikram R., Lee, Sun Jung, Lovitch, Scott B., Lian, Christine, Murphy, George F., Blazar, Bruce R., Vignali, Dario A.A., Freeman, Gordon J., Sharpe, Arlene H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543091/
https://ncbi.nlm.nih.gov/pubmed/33045061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182232
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