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PD-1 controls Lymph Node and Blood T Follicular Regulatory Cells

Newly defined CD4(+)CXCR5(+)FoxP3(+) T Follicular Regulatory (TFR) cells inhibit CD4(+)CXCR5(+)FoxP3(−) T Follicular Helper (TFH)-mediated humoral immunity. Although PD-1 is expressed by both cell types, the role of this inhibitory receptor on TFR differentiation is unknown. Here we show that PD-1/P...

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Detalhes bibliográficos
Main Authors: Sage, Peter T., Francisco, Loise M., Carman, Christopher V., Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788614/
https://ncbi.nlm.nih.gov/pubmed/23242415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2496
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