PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused primarily on effector T cells. Far less is known about PD-1 function in regulatory T (T reg) cells. To study the role of PD-1 in T reg cells, we gene...

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Vydáno v:J Exp Med
Hlavní autoři: Tan, Catherine L., Kuchroo, Juhi R., Sage, Peter T., Liang, Dan, Francisco, Loise M., Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L., Juneja, Vikram R., Lee, Sun Jung, Lovitch, Scott B., Lian, Christine, Murphy, George F., Blazar, Bruce R., Vignali, Dario A.A., Freeman, Gordon J., Sharpe, Arlene H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543091/
https://ncbi.nlm.nih.gov/pubmed/33045061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182232
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